Lef1 is overexpressed in human endometrial cancers.

<p>(A–J) H&E and Lef-1/DAPI staining of inactive (A, B) and proliferating (C, D) normal endometrium, and of endometrioid (E, F), papillary serous (G, H), and malignant mixed mullerian (I, J) endometrial cancers. (K–M) Quantification of Lef1 expression, as assessed by real-time PCR, in a variety of tumors and normal tissues: (K) in 99 independent endometrial tumor samples of mixed histology, and in inactive and proliferating (Prolif) normal endometrium; (L) in endometrioid tumors (Endo), papillary serous tumors (PapSer), malignant mixed mullerian tumors (MMMT), and inactive endometrium; and (M) in tumors by grade only within endometrioid histology, and in inactive endometrium. (N) Cyclin D1 and MMP7 expression in endometrial cancers of mixed histology and in inactive endometrium. Bars below plots indicate sample pairs for which p-values <0.05. Error bars represent SEM.