Lactosylceramide (LacCer) is the key branching point of sphingolipid biosynthesis.
- Yukinori Tsukuda (317544)
- Norimasa Iwasaki (317545)
- Naoki Seito (317546)
- Masashi Kanayama (317547)
- Naoki Fujitani (317549)
- Yasuro Shinohara (317551)
- Yasuhiko Kasahara (317553)
- Tomohiro Onodera (317554)
- Koji Suzuki (209461)
- Tsuyoshi Asano (317557)
- Akio Minami (317559)
- Tadashi Yamashita (317562)
Publication date
February 2013
DOIAbstract
<p>In the synthetic pathway of sphingolipids, four alternate pathways (lacto-series, neolacto-series, globo-series, and isoglobo-series) branch-off from LacCer. GM3S<sup>−/−</sup> mice, in which the GM3 synthase gene is disrupted, produced only o-series gangliosides, including GA2 and GA1, and not a-series or b-series gangliosides.</p
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