Persistence, surrounding residues, and halothane binding energies of putative volatile anesthetic binding sites at tubulin interfaces.

Molecular dynamics simulation of a synthetic four-α-helix bundle that binds the anesthetic halothane

Davies, Lowri A.
Klein, Michael L.
Scharf, Daphna

July 1999

AbstractThe structural features of binding sites for volatile anesthetics are examined by performing...

Binding of the volatile general anesthetics halothane and isoflurane to a mammalian beta-barrel protein.

Johansson, J.S.
Manderson, Gavin
Ramoni, R.
Grolli, S
Eckenhoff, R.G.

January 2005

A molecular understanding of volatile anesthetic mechanisms of action will require structural descri...

Binding of the volatile general anesthetics halothane and isofluorane to a mammalian beta barrel protein

JOHANSSON J. S.
MANDERSON G. A.
ECKENHOFF R. G.
RAMONI, Roberto
GROLLI, Stefano

January 2005

A molecular understanding of volatile anesthetic mechanisms of action will require structural descri...

Persistence, surrounding residues, and halothane binding energies of putative volatile anesthetic binding sites on a single αβ-tubulin dimer.

Travis J. A. Craddock (318229)
Marc St. George (318231)
Holly Freedman (318234)
Khaled H. Barakat (293854)
Sambasivarao Damaraju (102523)
Stuart Hameroff (318239)
Jack A. Tuszynski (160860)

February 2013

aResidues are numbered according to the scheme of Löwe et al. <a href="http://www.plosone.org/art...

Putative volatile anesthetic binding sites on the tubulin body.

Travis J. A. Craddock (318229)
Marc St. George (318231)
Holly Freedman (318234)
Khaled H. Barakat (293854)
Sambasivarao Damaraju (102523)
Stuart Hameroff (318239)
Jack A. Tuszynski (160860)

February 2013

(A) 47 total sites (red spheres) with persistence ranging from 0.80% to 100%. (B) 9 most persiste...

Molecular Dynamics And Binding Mechanisms Of Volatile Anesthetics Targeting Human Tubulin

Zizzi, Eric Adriano
Cavaglià, Marco
Deriu, Marco Agostino
Tuszynski, Jacek Adam

January 2021

Anesthesia, despite being the cornerstone of modern surgery, is to this date a biological puzzle. Wh...

Four-α-Helix Bundle with Designed Anesthetic Binding Pockets. Part II: Halothane Effects on Structure and Dynamics

Cui, Tanxing
Bondarenko, Vasyl
Ma, Dejian
Canlas, Christian
Brandon, Nicole R.
Johansson, Jonas S.
Xu, Yan
Tang, Pei

June 2008

AbstractAs a model of the protein targets for volatile anesthetics, the dimeric four-α-helix bundle,...

A Designed Four-α-Helix Bundle That Binds the Volatile General Anesthetic Halothane with High Affinity

Johansson, Jonas S.
Scharf, Daphna
Davies, Lowri A.
Reddy, Konda S.
Eckenhoff, Roderic G.

February 2000

AbstractThe structural features of volatile anesthetic binding sites on proteins are being examined ...

Computational Predictions of Volatile Anesthetic Interactions with the Microtubule Cytoskeleton: Implications for Side Effects of General Anesthesia

Craddock, Travis J.A.
George, Marc St.
Freedman, Holly
Barakat, Khaled H.
Damaraju, Sambasivarao
Hameroff, Stuart
Tuszynski, Jack A.

June 2012

The cytoskeleton is essential to cell morphology, cargo trafficking, and cell division. As the neuro...

Location and character of volatile general anesthetics binding sites in the transmembrane domain of TRPV1

Jorgensen, C
Domene, C

August 2018

It has been proposed that general anesthesia results from direct multisite interactions with multipl...

Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia

Craddock, Travis J. A.
George, Marc St.
Freedman, Holly
Barakat, Khaled H.
Damaraju, Sambasivarao
Hameroff, Stuart
Tuszynski, Jack A.

June 2012

The cytoskeleton is essential to cell morphology, cargo trafficking, and cell division. As the neuro...

Location and Character of Volatile General Anesthetics Binding Sites in the Transmembrane Domain of TRPV1

Christian Jorgensen (28321)
Carmen Domene (173398)

August 2018

It has been proposed that general anesthesia results from direct multisite interactions with multipl...

Tubulin isotype, sequence and halothane binding energy range for the C-terminal tail regions found in the brain.

Travis J. A. Craddock (318229)
Marc St. George (318231)
Holly Freedman (318234)
Khaled H. Barakat (293854)
Sambasivarao Damaraju (102523)
Stuart Hameroff (318239)
Jack A. Tuszynski (160860)

February 2013

aAdapted from Luduena et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pon...

Prediction of Volatile Anesthetic Binding Sites in Proteins

Streiff, John H.
Allen, Thomas W.
Atanasova, Elena
Juranic, Nenad
Macura, Slobodan
Penheiter, Alan R.
Jones, Keith A.

November 2006

AbstractComputational methods designed to predict and visualize ligand protein binding interactions ...

Effect of Four-alpha-Helix Bundle Cavity Size on Volatile Anesthetic Binding Energetics.

Manderson, Gavin
Michalsky, Stuart J
Johansson, Jonas S.

January 2003

Currently, it is thought that inhalational anesthetics cause anesthesia by binding to ligand-gated i...

Molecular dynamics simulation of a synthetic four-α-helix bundle that binds the anesthetic halothane

Davies, Lowri A.
Klein, Michael L.
Scharf, Daphna

July 1999

AbstractThe structural features of binding sites for volatile anesthetics are examined by performing...

Binding of the volatile general anesthetics halothane and isoflurane to a mammalian beta-barrel protein.

Johansson, J.S.
Manderson, Gavin
Ramoni, R.
Grolli, S
Eckenhoff, R.G.

January 2005

A molecular understanding of volatile anesthetic mechanisms of action will require structural descri...

Binding of the volatile general anesthetics halothane and isofluorane to a mammalian beta barrel protein

JOHANSSON J. S.
MANDERSON G. A.
ECKENHOFF R. G.
RAMONI, Roberto
GROLLI, Stefano

January 2005

A molecular understanding of volatile anesthetic mechanisms of action will require structural descri...

Persistence, surrounding residues, and halothane binding energies of putative volatile anesthetic binding sites on a single αβ-tubulin dimer.

Travis J. A. Craddock (318229)
Marc St. George (318231)
Holly Freedman (318234)
Khaled H. Barakat (293854)
Sambasivarao Damaraju (102523)
Stuart Hameroff (318239)
Jack A. Tuszynski (160860)

February 2013

aResidues are numbered according to the scheme of Löwe et al. <a href="http://www.plosone.org/art...

Putative volatile anesthetic binding sites on the tubulin body.

Travis J. A. Craddock (318229)
Marc St. George (318231)
Holly Freedman (318234)
Khaled H. Barakat (293854)
Sambasivarao Damaraju (102523)
Stuart Hameroff (318239)
Jack A. Tuszynski (160860)

February 2013

(A) 47 total sites (red spheres) with persistence ranging from 0.80% to 100%. (B) 9 most persiste...

Molecular Dynamics And Binding Mechanisms Of Volatile Anesthetics Targeting Human Tubulin

Zizzi, Eric Adriano
Cavaglià, Marco
Deriu, Marco Agostino
Tuszynski, Jacek Adam

January 2021

Anesthesia, despite being the cornerstone of modern surgery, is to this date a biological puzzle. Wh...

Four-α-Helix Bundle with Designed Anesthetic Binding Pockets. Part II: Halothane Effects on Structure and Dynamics

Cui, Tanxing
Bondarenko, Vasyl
Ma, Dejian
Canlas, Christian
Brandon, Nicole R.
Johansson, Jonas S.
Xu, Yan
Tang, Pei

June 2008

AbstractAs a model of the protein targets for volatile anesthetics, the dimeric four-α-helix bundle,...

A Designed Four-α-Helix Bundle That Binds the Volatile General Anesthetic Halothane with High Affinity

Johansson, Jonas S.
Scharf, Daphna
Davies, Lowri A.
Reddy, Konda S.
Eckenhoff, Roderic G.

February 2000

AbstractThe structural features of volatile anesthetic binding sites on proteins are being examined ...

Computational Predictions of Volatile Anesthetic Interactions with the Microtubule Cytoskeleton: Implications for Side Effects of General Anesthesia

Craddock, Travis J.A.
George, Marc St.
Freedman, Holly
Barakat, Khaled H.
Damaraju, Sambasivarao
Hameroff, Stuart
Tuszynski, Jack A.

June 2012

The cytoskeleton is essential to cell morphology, cargo trafficking, and cell division. As the neuro...

Location and character of volatile general anesthetics binding sites in the transmembrane domain of TRPV1

Jorgensen, C
Domene, C

August 2018

It has been proposed that general anesthesia results from direct multisite interactions with multipl...

Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia

Craddock, Travis J. A.
George, Marc St.
Freedman, Holly
Barakat, Khaled H.
Damaraju, Sambasivarao
Hameroff, Stuart
Tuszynski, Jack A.

June 2012

The cytoskeleton is essential to cell morphology, cargo trafficking, and cell division. As the neuro...

Location and Character of Volatile General Anesthetics Binding Sites in the Transmembrane Domain of TRPV1

Christian Jorgensen (28321)
Carmen Domene (173398)

August 2018

It has been proposed that general anesthesia results from direct multisite interactions with multipl...

Tubulin isotype, sequence and halothane binding energy range for the C-terminal tail regions found in the brain.

Travis J. A. Craddock (318229)
Marc St. George (318231)
Holly Freedman (318234)
Khaled H. Barakat (293854)
Sambasivarao Damaraju (102523)
Stuart Hameroff (318239)
Jack A. Tuszynski (160860)

February 2013

aAdapted from Luduena et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pon...

Prediction of Volatile Anesthetic Binding Sites in Proteins

Streiff, John H.
Allen, Thomas W.
Atanasova, Elena
Juranic, Nenad
Macura, Slobodan
Penheiter, Alan R.
Jones, Keith A.

November 2006

AbstractComputational methods designed to predict and visualize ligand protein binding interactions ...

Effect of Four-alpha-Helix Bundle Cavity Size on Volatile Anesthetic Binding Energetics.

Manderson, Gavin
Michalsky, Stuart J
Johansson, Jonas S.

January 2003

Currently, it is thought that inhalational anesthetics cause anesthesia by binding to ligand-gated i...

Molecular dynamics simulation of a synthetic four-α-helix bundle that binds the anesthetic halothane

Davies, Lowri A.
Klein, Michael L.
Scharf, Daphna

July 1999

AbstractThe structural features of binding sites for volatile anesthetics are examined by performing...

Binding of the volatile general anesthetics halothane and isoflurane to a mammalian beta-barrel protein.

Johansson, J.S.
Manderson, Gavin
Ramoni, R.
Grolli, S
Eckenhoff, R.G.

January 2005

A molecular understanding of volatile anesthetic mechanisms of action will require structural descri...

Binding of the volatile general anesthetics halothane and isofluorane to a mammalian beta barrel protein

JOHANSSON J. S.
MANDERSON G. A.
ECKENHOFF R. G.
RAMONI, Roberto
GROLLI, Stefano

January 2005

A molecular understanding of volatile anesthetic mechanisms of action will require structural descri...

Persistence, surrounding residues, and halothane binding energies of putative volatile anesthetic binding sites at tubulin interfaces.

Abstract

Extracted data

Persistence, surrounding residues, and halothane binding energies of putative volatile anesthetic binding sites at tubulin interfaces.

Abstract

Extracted data

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