Inhibition of farnesyl transferase or geranylgeranyl transferase I activity increases <i>Drosophila</i> lifespan.

<p>Shown in panel A are the lifespans of <i>Drosophila</i> in the absence of drugs [control (○)]; and in the presence of 5 µM (□); 10 µM (▵); or 20 µM (▾) L744832. The mean lifespan of flies treated with 5, 10, and 20 µM L744832 were significantly increased relative to control (P = 0.0089, P<0.0001, and P = 0.0019, respectively). In panel B are shown the lifespans of <i>Drosophila</i> in the absence of drugs [control (○)]; and in the presence of 100 µM (▵) or 300 µM (▾) GGTI-298. The mean lifespan of flies treated with 100 and 300 µM GGTI-298 was significantly increased relative to control (P<0.0001 and P<0.0001, respectively).