Multiorgan metastatic ability of human breast cancer cell lines in Rag2^−/−;Il2rg^−/− mice.

a<p>Table includes only those mice for which all indicated metastatic sites were homogeneously evaluable, excluding, for example, those cases in which selected organs were separately processed for morphologic or immunohistochemical studies (<i>see</i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039626#pone-0039626-g002" target="_blank">Fig. 2</a>).</p>b<p>Other metastatic sites include salivary glands, snout, uterus, interscapular space.</p>c<p>Mice were sacrificed when they showed signs of distress; mean ± standard error of the mean survival times in weeks were: MDA-MB-453: 9.1±0.32; 453-EGFP: 8.4±0.57; BT-474: 28.9±3.36; 474-EGFP: 59.3±4.92.