Aquaporins.

<p>Aquaporins 1, 4, and 5 in the inner ear (A-C) and middle ear (D-G). A: AQP1 in the inner ear showed positive staining of the lateral lining of the spiral ligament and some fibrocytes within the spiral ligament. B: AQP4 in the inner ear positively stained bone of the otic capsule, organ of Corti, and spiral ganglion. C: AQP5 showed mild labeling of the inner ear organ of Corti. D: AQP 1 antibody stained the middle ear epithelial submucosa and capillary endothelium. E and F: Middle ear AQP4 labeled the middle ear epithelium itself and portions of the ossicular bones, malleus and incus. G: AQP5 in the middle ear appeared limited to the apical membranes of the epithelium. Negative controls are displayed as inset pictures. [SV, stria vascularis; SM, scala media; SL, spiral ligament; RM, Reissner’s membrane; OC, organ of Corti; ST scala tympani; MEE, middle ear epithelium; SUB, submucosa; MES, middle ear space; M, malleus; I, incus].