Screen of compounds derived from Chinese herbal remedies led to the identification of fangchinoline as a novel anti-HIV-1 agent.

<p>(A) MT-4 cells were infected with HIV-1 LAI at an MOI of 0.1 or mock infected in the presence of serially diluted test compounds. Cell viability was measured 5 days post-infection. The anti-HIV activity of each compound was presented as the maximum inhibition of CPE at various concentrations. (B) The chemical structure of fangchinoline.