Phylogenetic tree of CYP2D amino acid sequences and genomic structures of human <i>CYP2D6</i> and chicken <i>CYP2D49</i>.

<p>(A) Phylogeny of CYP2D amino acid sequences from the chicken and other animal species. The neighbor-joining tree was created using the Molecular Evolutionary Genetics Analysis Version 4 software. The numbers on the branches indicate the number of times per 100 bootstrap replicates that the branch appeared in the trees, estimated by a random resampling of the data. Only bootstrap values greater than 50% are shown. The scale bar represents 5 substitutions in 100 residues. (B) Genomic structures of human <i>CYP2D6</i> and chicken <i>CYP2D49</i>. The diagram of the organization of the <i>CYP2D</i> subfamily in humans and chickens was determined by the BLAT analysis of the human and chicken genome data from NCBI database. Exons are indicated by boxes, whereas introns are indicated by lines. The lengths of the exons and introns are expressed in base pairs. The arrowheads indicate the direction of transcription.