Altered MMP to TIMP ratios in filarial infection and lymphedema.

<p>(A) Ratio of circulating levels of MMP-1/TIMP-4 and MMP-8/TIMP-4 from filarial lymphedema individuals with active infection [CP Ag+] and asymptomatic infected [INF] individuals as well as from filarial lymphedema individuals without active infection [CP Ag−] and endemic normal [EN] individuals are shown. (B) Ratio of circulating levels of MMP-1/TIMP-2, MMP-7/TIMP-1, and MMP-7/TIMP-2 from filarial lymphedema individuals with active infection [CP Ag+] and asymptomatic infected [INF] individuals as well as from filarial lymphedema individuals without active infection [CP Ag−] and endemic normal [EN] individuals are shown. P values were calculated using the Mann-Whitney test.