Individuals who are DR*04+ and have detectable HIV RNA have a greater risk of neurocognitive decline.

<p>Values (other than sample N) in tables represent averages of the indicated variables. BL is baseline score and 012 is twelve-month evaluation point. “Decline” is significant neurocognitive decline between BL and 012 (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032303#s2" target="_blank">methods</a>). Percent ART is percentage of group on at least 2 anti-retroviral medications. CD4 values are absolute cells/microliter. HRNA log is log value of HIV RNA copies/ml with a lower limit of detection of 50 copies. All statistical tests are two tailed, values <.05 are underlined. A p value with an asterisk denotes Fisher’s Exact Test and others were derived using Wilcoxen non-parametric test.