BACKGROUND: Obesity is associated with impaired vascular function. In the cardiovascular system, protease-activated receptor 2 (PAR2) exerts multiple functions such as the control of the vascular tone. In pathological conditions, PAR2 is related to vascular inflammation. However, little is known about the impact of obesity on PAR2 in the vasculature. Therefore, we explored the role of PAR2 as a potential link between obesity and cardiovascular diseases. METHODS: C57BL/6 mice were fed with either a chow or a 60% high fat diet for 24 weeks prior to isolation of aortas. Furthermore, human coronary artery endothelial cells (HCAEC) and human coronary smooth muscle cells (HCSMC) were treated with conditioned medium obtained from in vitro differen...
Human adipose stem cells (hASCs) can promote angiogenesis through secretion of proangiogenic factors...
Objective: Angiotensin II (Ang II), endothelin-1 (ET-1) and reactive oxygen species (ROS) have been ...
Vascular system is constituted by a complex and articulate network, e.g. arteries, arterioles, venul...
Proteinase-activated receptor 2 (PAR2) is a cell surface receptor activated by serine proteinases or...
Proteinase-activated receptor 2 (PAR2) is a cell surface receptor activated by serine proteinases or...
Aim: To investigate protease activated receptor 2 (PAR-2) expression in human coronary atherosclerot...
Cardiometabolic disorders, including obesity-related insulin resistance and atherosclerosis, share s...
AIM: To investigate protease activated receptor 2 (PAR-2) expression in human coronary atherosclerot...
AIM: To investigate protease activated receptor 2 (PAR-2) expression in human coronary atheroscl...
Background: The coagulation system is closely linked with vascular inflammation, although the underl...
Objective - Proteinase-activated receptor-2 is widely expressed in vascular tissue and in highly vas...
Objective—Proteinase-activated receptor-2 is widely expressed in vascular tissue and in highly vascu...
Angiotensin II (Ang II) plays an important role in cardiovascular disease. It also leads to the acti...
We investigated if new vessel formation in fat involves the contribution of local tissue-derived end...
SummaryRecent studies of obesity have provided new insights into the mechanisms underlying insulin r...
Human adipose stem cells (hASCs) can promote angiogenesis through secretion of proangiogenic factors...
Objective: Angiotensin II (Ang II), endothelin-1 (ET-1) and reactive oxygen species (ROS) have been ...
Vascular system is constituted by a complex and articulate network, e.g. arteries, arterioles, venul...
Proteinase-activated receptor 2 (PAR2) is a cell surface receptor activated by serine proteinases or...
Proteinase-activated receptor 2 (PAR2) is a cell surface receptor activated by serine proteinases or...
Aim: To investigate protease activated receptor 2 (PAR-2) expression in human coronary atherosclerot...
Cardiometabolic disorders, including obesity-related insulin resistance and atherosclerosis, share s...
AIM: To investigate protease activated receptor 2 (PAR-2) expression in human coronary atherosclerot...
AIM: To investigate protease activated receptor 2 (PAR-2) expression in human coronary atheroscl...
Background: The coagulation system is closely linked with vascular inflammation, although the underl...
Objective - Proteinase-activated receptor-2 is widely expressed in vascular tissue and in highly vas...
Objective—Proteinase-activated receptor-2 is widely expressed in vascular tissue and in highly vascu...
Angiotensin II (Ang II) plays an important role in cardiovascular disease. It also leads to the acti...
We investigated if new vessel formation in fat involves the contribution of local tissue-derived end...
SummaryRecent studies of obesity have provided new insights into the mechanisms underlying insulin r...
Human adipose stem cells (hASCs) can promote angiogenesis through secretion of proangiogenic factors...
Objective: Angiotensin II (Ang II), endothelin-1 (ET-1) and reactive oxygen species (ROS) have been ...
Vascular system is constituted by a complex and articulate network, e.g. arteries, arterioles, venul...