Modulation of NMDA receptor subunits expression by chronic stress and antidepressant treatment <i>in rat brain.</i>

<p>The mRNA levels of GluN1 <i>(</i><b><i>A, D, G</i></b><i>),</i> GluN2A <i>(</i><b><i>B, E, H</i></b><i>)</i> and GuN2B <i>(</i><b><i>C, F, I</i></b><i>)</i> were measured in ventral hippocampus <i>(</i><b><i>A, B, C</i></b><i>), </i><b><i>dorsal hippocampus</i></b><i> (</i><b><i>D, E, F</i></b><i>) </i><b><i>and prefrontal cortex</i></b><i> (</i><b><i>G, H, I</i></b><i>)</i> of non stressed and chronically stressed rats, treated for 21 days with vehicle or duloxetine and killed 24 hours after the last stress. The data, expressed as a percentage of No Stress/Vehicle (set at 100%), are the mean ± SEM of at least 10–12 independent determinations. *p<0.05, **p<0.01, ***p<0.01 vs. No Stress/Vehicle; <i>^$</i><b><i>p<0.05</i></b>, ^$$$p<0.001 vs. Stress/Vehicle (two-way ANOVA with SCPHT).