Increased TNFR1/TNFR2 ratio during aging.

<p><b><i>A,</i></b> Representative Western blots for TNFR1 and TNFR2 in hippocampal membrane fractions from young (6 mos; <i>n</i> = 6) and aged (22 mos; <i>n = </i>10) male Fischer rats, with the Na/K-ATPase loading control shown below. <b><i>B,</i></b> There was no significant change in TNFR1 protein levels with age (<i>p</i> = 0.67); however, there was a significant decrease in TNFR2 with age (* <i>p</i><0.05).