Collagen deposition in the renal cortex, peritubular and surrounding the glomeruli in CD73^−/−mice.

<p>(A) Representative images of fibrillar collagen deposition shown by Sirius Red staining (in CD73^−/−as compared to WT controlc mice, ×200 magnification). (B) Image analysis demonstrates that CD73^−/−mice exhibit increased levels of fibrillary collagen deposition within the cortex compared with WT controls (significance as indicated, p<0.002 CD73^−/− vs WT mice, Sirius red staining, 3–5 images per animal, n = 7 animals/group, Student t-test).