Nilotinib plus doxorubicin-treated leiomyosarcoma SK-UT-1 cells showed prolonged inhibition of cell growth after drug withdrawal.

<p>Cells were pre-treated with vehicle or nilotinib for 24 h, and DXR (0.05 µM) was then added to the corresponding wells and treatment continued for another 72 h. Cells were then recovered, diluted and reseeded at a density of 1.8×10⁴ cell per well with culture medium without any further compounds. After 12 days, cells were counted using a hemocytometer. Values are mean ± SEM of three independent experiments. ^*<i>P</i><0.05 and ^**<i>P</i><0.01 versus DXR-treated cells.