Increased striatal GluN2B^Tyr-1472 phosphorylation in LCRs after acute cocaine.

<p>(<b>a</b>) The level of NMDAR pGluN2B ^Tyr-1472 was selectively increased in dSTR of LCRs, compared to HCRs and saline controls, at 40 min after an acute 10 mg/kg i.p. cocaine injection (group 1, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037673#pone-0037673-t001" target="_blank">Table 1</a>). Representative western blots are shown in the panel above the bars. Mean values ±SEM for the ratios of pGluN2B^Tyr-1472 to total GluN2B in dSTR are shown for each treatment. Saline: n = 7, LCR: n = 8, HCR: n = 7. ** p<0.01: LCR vs. HCR, LCR vs. Saline. One Saline and one HCR were removed from the analysis (see Methods, Data Analysis). (<b>b</b>) For all of the cocaine-treated rats, there was a significant negative correlation between cocaine-induced locomotor activity and pGluN2B^Tyr-1472 levels in the dSTR; r² = 0.3905, p<0.05; n = 15. LCR = open triangle, HCR = closed square. One HCR was removed from the analysis (see Methods, Data Analysis).