Analysis of dopamine signaling defects in <i>rsbp-1</i> mutants.

<p>(A), Dose-response curves measuring locomotion behavior in response to exogenous dopamine. Shown are the percentages of animals moving 20 min after being placed on agar plates containing the indicated concentrations of dopamine. Each data point represents the mean ± standard error of the mean for three trials totaling at least 75 animals. (Two way ANOVA with Bonferroni post hoc test, *p<0.0001, ^§p<0.01, ^†p<0.05 when compared to the wildtype). (B), Quantitative analysis of basal slowing behavior. For each strain, locomotion rates in the absence of bacteria (white bars) and presence of bacteria (black bars) were calculated as the average of 30 observations. Error margins shown indicate 95% confidence intervals. Asterisks indicate values significantly different from the 45% slowing seen in the wildtype. (One-way ANOVA with Bonferroni post hoc test, asterisks indicate p<0.001). The percent slowing in the presence of bacteria for each strain is shown at the right. <i>rsbp-1</i> mutants are defective in endogenous dopamine signaling.