Quantitative behavioral analysis of wild-type and <i>rsbp-1</i>, <i>eat-16</i>, and <i>egl-10</i> mutant animals.

<p>(A), SWIP behavior of wild-type or mutant animals. Each measurement shown represents the mean of five trials of 10 L4 animals each for a total of 50 animals per strain. Error bars represent 95% confidence intervals. All strains were compared using one-way ANOVA with Bonferroni post hoc test. Only <i>dat-1</i> and <i>egl-10</i> single mutants, <i>dat-1; egl-10</i> double mutants, and <i>rsbp-1</i>; <i>dat-1</i>; <i>egl-10</i> triple mutants were statistically different from the wildtype (p<0.001). (B), Dose-response curves measuring paralysis induced by exogenous dopamine. Shown are the percentages of animals moving 20 min after being placed on agar plates containing the indicated concentrations of dopamine. Each data point represents the mean ± standard error of the mean (s.e.m.) for three trials totaling at least 75 animals. The responses of <i>eat-1</i> and <i>rsbp-1</i> mutants are not statistically different from each other at any concentration of dopamine. The response of <i>egl-10</i> mutants is significantly different from the wild-type at the indicated concentrations of dopamine (Two way ANOVA with Bonferroni post hoc test, *p<0.0001, ^§p<0.01).