Detection of the free copper and protein-bound copper in the brain of tx and DL mice.

<p>(A)(C)The free copper concentrations in the cortex and basal ganglia of tx mice increased on the 3rd day and decreased on the 10th and 14th day,respectively. In DL mice the free copper decreased slightly along the administration. (B)(D) The protein-bound copper concentrations in the cortex and basal ganglia of tx and DL mice all decreased along the administration. The protein-bound copper concentrations in tx mice were about 2-fold higher than that of DL mice. (* P<0.05; ** P<0.01).