Antibody responses specific for H1N1 vaccine antigens in vaccinated cynomolgus macaques.
- Masahiko Arikata (322470)
- Yasushi Itoh (322471)
- Masatoshi Okamatsu (322472)
- Toshinaga Maeda (322473)
- Takashi Shiina (18405)
- Keiko Tanaka (83031)
- Shingo Suzuki (67899)
- Misako Nakayama (322477)
- Yoshihiro Sakoda (322479)
- Hirohito Ishigaki (322482)
- Ayato Takada (18295)
- Hideaki Ishida (322484)
- Kosuke Soda (322488)
- Van Loi Pham (322491)
- Hideaki Tsuchiya (322493)
- Shinichiro Nakamura (322494)
- Ryuzo Torii (322496)
- Takeshi Shimizu (120443)
- Hidetoshi Inoko (3038)
- Iwao Ohkubo (322499)
- Hiroshi Kida (21628)
- Kazumasa Ogasawara (322500)
Publication date
February 2013
DOIAbstract
<p>Cynomolgus macaques were subcutaneously immunized twice (in weeks 0 and 2) with a whole virus particle vaccine (#312, #775 and #784, orange symbols) or with a split vaccine (#729, #742 and #750, blue symbols) derived from Hokkaido2. Sera and swab samples were collected in indicated weeks after the first vaccination. IgM (A), IgG (B, E), IgA (C, F), and IgG1 (D) antibodies specific for Hokkaido2 antigens in sera (A-D) and nasal swab samples (E, F) were analyzed using ELISA. Optical densities at 450 nm are shown. In IgM and IgA measurements (A, C, F), the OD450 values before vaccination as non-specific background responses were subtracted from those after vaccination.</p
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