NK1.1+ NK cells are partially required for the subsequent accumulation of influenza-specific CD8 T cell accumulation at the site of infection.

<p>Beginning on the day of infection, mice received i.v. injections of either PBS vehicle control or αNK1.1 (PK136) every other day until day 6 p.i. (red arrows), and indicated tissues were collected on days 4, 6, and 8 p.i. (A). Mean number NK cells cells on day 4 p.i. in untreated (black bars) and PK136-treated (open bars) are shown ± SEM (n = 3 mice/group) (B). Mean number of NP-Tet⁺ CD8 T cells in the BAL, lung, and spleen were quantified and depicted ± SEM on day 6 (C) and day 8 (D) p.i. (n = 3 mice/group). Stars indicate statistical significance (*p = 0.009). Data are representative of three independent experiments.