IFN-β induces senescence in K38 cells.
- Maria V. Chiantore (322949)
- Serena Vannucchi (322950)
- Rosita Accardi (269874)
- Massimo Tommasino (8382)
- Zulema A. Percario (208470)
- Gabriele Vaccari (51242)
- Elisabetta Affabris (208501)
- Gianna Fiorucci (208473)
- Giovanna Romeo (208495)
Publication date
February 2013
DOIAbstract
<p>(A) Control keratinocytes (LXSN), K16, K38 cells and high risk HPV-positive squamous carcinoma cell lines ME-180, Caski, HeLa and SiHa were treated with IFN-β for 4 days and senescent cells were quantified by counting cells displaying senescent-associated β-galactosidase (SA-βgal) activity at pH 6.0. (B) Percentage of senescent cells in K16 and K38 cells treated with IFN-β for different time points. (C) SA-βgal-positive K38 blue cells observed under a light microscope after 4 days of IFN-β treatment. * = p<0.05; *** = p<0.001.</p
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