Lung pathology in mice after immunization and RSV infection.

<p>Mice were immunized and challenged as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036812#pone-0036812-g002" target="_blank">Figure 2</a> and the lungs were harvested, sliced and stained with H&E and assessed for pathology using light microscopy. Panels represent the lungs of (A) FI-RSV, (B) live virus, (C) RSV virosomes, (D) RSV MPLA virosomes (E) buffer immunized mice. Black arrows point to alveolar infiltrates, grey arrows to peribronchial infiltrates and white arrows to perivascular infiltrates. (F) Eosinophils in BAL expressed as percentage of total BAL cells. Data points represent values from individual mice. Statistical differences were calculated using the ANOVA test with Bonferroni correction for multiple testing. ***p<0.001. The data shown are a representative of two individual experiments.