<p>Affinities were determined by insulin competition binding in a scintillation proximity assay; data are means (± SD) of quadruplicates (solubilised receptors) or duplicates (membrane-bound receptors).</p
Insulin and insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) are related protein hormones with dif...
We studied the nature of insulin receptor binding in MCF-7 breast cancer cells. In both intact cells...
AIMS/HYPOTHESIS: There is controversy with respect to molecular characteristics of insulin analogues...
<p>Receptor binding affinities for the solubilised IR-A (light teal), IR-B (dark teal) and IGF-IR (g...
<p>IC50 values were determined in scintillation proximity assays for displacement of <sup>125</sup>I...
<p>Binding of the insulin analogs to the human IR-A (<b>A</b>) or IR-B (<b>B</b>) was analyzed in a ...
a<p>Relative receptor binding affinity (potency) is defined as (<i>K<sub>d</sub></i> of human insuli...
<p>All assays were performed in at least three independent experiments. Data are means ± SD and pres...
Equilibrium binding of insulin to human insulin antibodies from diabetic subjects has been studied b...
Insulin receptors were solubilized from rat liver microsomes by the nonionic detergent Triton X-100....
Insulin and insulin-like growth factor-I exhibit a set of non-classical receptor binding properties ...
Treatment of the soluble insulin receptor from human placenta with 1.25 mM dithiothreitol and 75 mM ...
Originally published online on December 3, 2007To investigate the interaction of the insulin-like gr...
Insulin receptors on RINm5F cell membranes (an insulin-producing rat pancreatic cell line) were stud...
<p>Results are presented as absorbance (arbitrary value) mean ± SE, n = 4. IR, insulin receptor; IGF...
Insulin and insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) are related protein hormones with dif...
We studied the nature of insulin receptor binding in MCF-7 breast cancer cells. In both intact cells...
AIMS/HYPOTHESIS: There is controversy with respect to molecular characteristics of insulin analogues...
<p>Receptor binding affinities for the solubilised IR-A (light teal), IR-B (dark teal) and IGF-IR (g...
<p>IC50 values were determined in scintillation proximity assays for displacement of <sup>125</sup>I...
<p>Binding of the insulin analogs to the human IR-A (<b>A</b>) or IR-B (<b>B</b>) was analyzed in a ...
a<p>Relative receptor binding affinity (potency) is defined as (<i>K<sub>d</sub></i> of human insuli...
<p>All assays were performed in at least three independent experiments. Data are means ± SD and pres...
Equilibrium binding of insulin to human insulin antibodies from diabetic subjects has been studied b...
Insulin receptors were solubilized from rat liver microsomes by the nonionic detergent Triton X-100....
Insulin and insulin-like growth factor-I exhibit a set of non-classical receptor binding properties ...
Treatment of the soluble insulin receptor from human placenta with 1.25 mM dithiothreitol and 75 mM ...
Originally published online on December 3, 2007To investigate the interaction of the insulin-like gr...
Insulin receptors on RINm5F cell membranes (an insulin-producing rat pancreatic cell line) were stud...
<p>Results are presented as absorbance (arbitrary value) mean ± SE, n = 4. IR, insulin receptor; IGF...
Insulin and insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) are related protein hormones with dif...
We studied the nature of insulin receptor binding in MCF-7 breast cancer cells. In both intact cells...
AIMS/HYPOTHESIS: There is controversy with respect to molecular characteristics of insulin analogues...