Proposed mechanism of inotilone inhibition of LPS-induced inflammation in RAW 264.7 cells.

<p>Inotilone abrogates the phosphorylation of MAPKs/IKK and subsequently inactivates NF-κB, which may result from inotilone down-regulation of iNOS and COX-2. Arrows indicate the main inflammatory pathway activated by LPS stimulation. The prohibition signs indicate the inhibitory effects of inotilone. TLR4; Toll-like receptor 4.