Lipopolysaccharide (LPS) and unconjugated bilirubin (UCB) disrupt the endothelial monolayer.

<p>Permeability to sodium fluorescein (Na-F_Pe) (A) and transendothelial electrical resistance (TEER) (B) were determined after exposure. All values presented are means ± S.E.M. from at least four independent experiments performed in duplicate. *<i>P<</i>0.05, **<i>P<</i>0.01 and ***<i>P<</i>0.001 <i>vs.</i> respective control; ^§<i>P<</i>0.05 <i>vs.</i> LPS at the same time-point;^#<i>P</i><0.05 from 4 h.