GFAP-DNSynCAM1 mice have increased spontaneous locomotor activity that is attenuated by amphetamine.

<p>(<b>A</b>) Illustration depicting the behavior paradigm used to assess spontaneous locomotor activity and response to amphetamine in the open field. Adult male GFAP-DNSynCAM1 (n = 8) and WT littermates (n = 5) were subjected to the following paradigm during the dark (active) phase of the light cycle: 4 h of habituation, followed by 2 h of spontaneous locomotor activity post saline injection, followed by 2 h of locomotor activity after injection of D,L- amphetamine (4 mg/kg). (<b>B</b>) Total distance traveled (cm) in 1 hour time bins by GFAP-DNSynCAM1 (black circles) and WT littermates (white squares) during the habituation period. (<b>C</b>) Total distance traveled (cm) in 10 minute time bins by GFAP-DNSynCAM1 (black circles) and WT littermates (white squares) immediately following a subcutaneous injection of saline. Inset is the average distance traveled (cm) by each mouse during the first and second hours of behavior assessment. (<b>D</b>) Total distance traveled (cm) in 10 min bins by GFAP-DNSynCAM1 (black circles) and WT littermates (white squares) immediately following a subcutaneous injection of D,L- amphetamine (4 mg/kg). For all graphs the data points are represented as means ± SEM. Panels B–D were analyzed using a repeated measures ANOVA (time by genotype) followed by an unpaired t-test for each time point (panel D). Data shown in the inset to panel C were analyzed by a two way ANOVA (time by genotype) followed by a Student-Newman-Keuls post hoc test. * p<0.05.