Ablation of Sim1 neurons causes hyperphagic obesity.

<p>(A) Growth curves and (B) weekly food intake of Sim1creiDTR versus iDTR mice. 2.5 ng DT was ICV injected at wk 5. Body weight and food intake were measured weekly on a chow diet (n = 7 for each group, *p<0.05). (C) Hypothalamic mRNA expression of Sim1creiDTR mice versus iDTR mice (n = 4 for each group, *p<0.05). (D) Representative images of iDTR and Sim1creiDTR mice (wk 14). (E) Relationship between final body weight and hypothalamic <i>Sim1</i> mRNA levels of Sim1creiDTR mice and iDTR mice. (F) Feeding efficiency calculated as the ratio between weekly body weight change (g) and food intake (g) (n = 7 for each group, *p<0.05). (G) Body composition measured by NMR (n = 4 for each group, *p<0.05; **p<0.01). Error bars indicate SEM for all figures. Means at each time point or condition were compared by a two-tailed <i>t</i>-test, with Welch's correction.