Dose-dependent suppression of splenocyte proliferation by hAEC.

<p>(<b>A</b>) ConA (5 µg/ml) stimulated proliferation of splenocytes from naive mice was dose-dependently inhibited by hAEC in hAEC∶splenocyte ratios ranging from 1∶5 to 1∶10240 (n = 5). (<b>B</b>) Proliferation of splenocytes from EAE mice stimulated by 1 µg/ml and 10 µg/ml MOG peptide was inhibited by hAEC (n = 3) at hAEC∶splenocyte ratios of 1∶10 and 1∶40. Splenocyte proliferation is expressed as counts per minute (cpm) of ³H-thymidine incorporation. All data are means±SEM.