Fibrin crosslinking by FXIIIa.
- Katharina Hess (5652307)
- Ramzi Ajjan (325639)
- Fladia Phoenix (12324)
- József Dobó (325640)
- Péter Gál (325641)
- Verena Schroeder (325642)
Publication date
February 2013
DOIAbstract
<p>When thrombin or MASP-1 were incubated with NCP or FXIII-DP with added FXIII, γ-γ dimers and αn polymers were formed. No crosslinks were formed in FXIII-DP. Lane 1: Molecular weight marker. Lane 2: Purified fibrinogen. Lane 3: NCP+Ca<sup>2+</sup>+thrombin. Lane 4: NCP+Ca<sup>2+</sup>+MASP-1. Lane 5: FXIII-DP+Ca<sup>2+</sup>+thrombin. Lane 6: FXIII-DP+Ca<sup>2+</sup>+MASP-1. Lane 7: FXIII-DP+FXIII+Ca<sup>2+</sup>+thrombin. Lane 8: FXIII-DP+FXIII+Ca<sup>2+</sup>+MASP-1. Lane 9: Purified fibrinogen. Lane 10: Molecular weight marker.</p
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