Treg model shows improved effector cell dynamics over previously published fits.

<p>(A,C) Plot of modeled uninfected T-cell population (blue), normal Treg (green) and adaptive Treg populations (purple). Models correspond to best fits to the viral load data from two separate representative patients. (inset) Patient data is shown (circular data points), and viral load is shown (red). Parameter values for simulations can be found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033924#pone-0033924-t001" target="_blank">Table 1</a>. (B,D) Comparative plots of effector populations using Treg model as compared to a previously published model <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033924#pone.0033924-Ciupe1" target="_blank">[9]</a> as well as physiological ranges for effector cells <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033924#pone.0033924-Banacloche1" target="_blank">[10]</a> as seen by the red horizontal lines in B and D. In all cases, we notice that our model does not dip to unrealistic ranges initially as does the Ciupe model. However, the viral load fits between both models are nearly the same suggesting a degree of robustness between both models.