<p>Comparisons of the CVs for EPSP properties calculated over the entire dendritic population, or for inputs restricted to the first 700 µm (70% of inputs) or last 300 µm (30% of inputs) of the dendrite. Left, local EPSPs at spine (red traces) or shaft (blue traces) inputs along the first 700 µm (∼100 µm intervals). Middle, local spine and shaft EPSPs generated along the last 300 µm of dendrite. Right, local EPSPs along the entire dendrite. CVs for EPSP amplitude (indicted in light blue) and half-width (indicated in green) were calculated for all inputs located within the dendritic subregions (n = 70, 30, and 100, respectively, for first 70%, last 30%, and entire synapse population).</p
(A) Performance (i.e., maximal rate modulation, see Fig 2C; black curve) and energy costs (blue curv...
<p>(A) A color plot of spine signature shows that only a few of the non-stimulated spines have a sig...
© 2017 Elsevier Inc. Since Cajal's first drawings of Golgi stained neurons, generations of researche...
Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the...
<p>A<sub>1</sub>–D<sub>1</sub>) Morphology of reconstructed neurons: A<sub>1</sub>) layer 5 pyramida...
Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the...
Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the...
<p><b>A</b>. Illustration of dendritic branch, showing the decay of the EPSP traveling from either t...
<p>A. Top: two-photon reconstruction of imaged cell. Rectangles show recording site at the apical an...
<p>(<b>A-D</b>) EPSPs at different locations along a single dendritic branch (branch 3), as a respon...
<p>(A) Ratio of active PKC to 2AG versus spine for both theta burst stimulation (TBS) and 20 Hz stim...
(A) Schematic showing a spine, made of a spine head compartment and a spine neck compartment, placed...
(A) Kymographs showing the spatiotemporal spread of voltage (top) and calcium (middle) and pCaMKII (...
<p>(<b>A-C</b>) EPSP amplitude () as a function of distance from soma in 3 different branches (each ...
(A) Kymographs depicting the spatiotemporal spread of microdomains along the biochemical signaling c...
(A) Performance (i.e., maximal rate modulation, see Fig 2C; black curve) and energy costs (blue curv...
<p>(A) A color plot of spine signature shows that only a few of the non-stimulated spines have a sig...
© 2017 Elsevier Inc. Since Cajal's first drawings of Golgi stained neurons, generations of researche...
Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the...
<p>A<sub>1</sub>–D<sub>1</sub>) Morphology of reconstructed neurons: A<sub>1</sub>) layer 5 pyramida...
Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the...
Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the...
<p><b>A</b>. Illustration of dendritic branch, showing the decay of the EPSP traveling from either t...
<p>A. Top: two-photon reconstruction of imaged cell. Rectangles show recording site at the apical an...
<p>(<b>A-D</b>) EPSPs at different locations along a single dendritic branch (branch 3), as a respon...
<p>(A) Ratio of active PKC to 2AG versus spine for both theta burst stimulation (TBS) and 20 Hz stim...
(A) Schematic showing a spine, made of a spine head compartment and a spine neck compartment, placed...
(A) Kymographs showing the spatiotemporal spread of voltage (top) and calcium (middle) and pCaMKII (...
<p>(<b>A-C</b>) EPSP amplitude () as a function of distance from soma in 3 different branches (each ...
(A) Kymographs depicting the spatiotemporal spread of microdomains along the biochemical signaling c...
(A) Performance (i.e., maximal rate modulation, see Fig 2C; black curve) and energy costs (blue curv...
<p>(A) A color plot of spine signature shows that only a few of the non-stimulated spines have a sig...
© 2017 Elsevier Inc. Since Cajal's first drawings of Golgi stained neurons, generations of researche...