Cytokine ratios.

<p>Significant differences between different cytokine ratios are depicted, detected with a one way between-groups analysis of variance using the tukey test for post hoc analysis. Data from 60 patients with pulmonary TB (light grey), 27 extrapulmonary TB (dark grey) and 91 with non-tuberculous diseases (white) are depicted. Boxes and whiskers are displayed, the black line marks the median. Percentile ranges are additionally shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035290#pone-0035290-t003" target="_blank">Tables 3</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035290#pone-0035290-t004" target="_blank">4</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035290#pone-0035290-t005" target="_blank">5</a>. (A) shows statistically significant differences between non-tuberculous diseases and pulmonary TB: PPD induced IFN-γ/IL-2 (p<0.001), ESAT-6 induced TNF-α/IFN-γ (p = 0.048), TNF-α/IL-2 (p = 0.03), IFN-γ/IL-2 (p = 0.005), all CD4⁺ T cell derived. (B) shows statistically significant differences between non-tuberculous diseases and extrapulmonary TB: PPD induced TNF-α/IL-2 (p<0.001), IFN-γ/IL-2 (p = 0.001), ESAT-6 induced TNF-α/IFN-γ (p = 0.026), TNF-α/IL-2 (p = 0.008), IFN-γ/IL-2 (p<0.001), CD4⁺ T cell derived. (C) shows statistically significant differences between pulmonary TB and extrapulmonary TB: PPD induced TNF-α/IL-2 (p = 0.001), CD4⁺ T cell derived.