Diabetes increases A_2AR density and decreases A₁R density in hippocampal nerve terminals.

<p>A_2AR (A) and A₁R density (B) were measured as the specific binding of a supra-maximal concentration (6 nM) of the selective antagonists of A_2AR (³H-SCH58261) and A₁R (³H-DPCPX) in membranes from hippocampal nerve terminals of control (open bar), diabetic (black bars), diabetic treated with caffeine (grey bar) and control treated with caffeine (striped bars) (n = 5–6). Panel (C) displays a Western blot comparing A₁R immunoreactivity in control or diabetic (Diab) mice without or with caffeine (Caff) treatment, as well as the average results of A₁R immunoreactivity (% of control) in 6 such experiments. *P<0.05 <i>versus</i> control.