MIC-1/GDF15 overexpression improves glucose tolerance in mice on a high fat diet.

<p>A. Blood glucose concentrations in response to i.p. glucose injection (1 g/kg) in mice overexpressing MIC-1/GDF15 (MIC-1^fms) and control mice (MIC-1^+/+) at 23 weeks of age, after 13 weeks on a high fat diet. B. Area under the curve calculated from the glucose tolerance test in (A). C. Blood glucose concentrations in response to i.p. insulin injection (1 U/kg) in MIC-1^fms and MIC-1^+/+ mice at 24 weeks of age, after 14 weeks on a high fat diet. Data are means ± SEM of 5 female mice per group. *p&lt;0.05, **p&lt;0.01 and ***p&lt;0.001 for the difference between genotypes.