The effects of artemisinin on LPS-induced degradation and phosphorylation of IκB-α.

<p>(A) After treatment with artemisinin (10 µM) or PDTC (a specific inhibitor of NF-κB, 300 µM) for 24 h, primary rat microglia were stimulated with LPS (1 µg/ml) for 30 min. The LPS-induced degradation and phosphorylation of IκB-α were analyzed by western blot analysis. (B and C) Data are presented as the means ± S.E.M. from five separate experiments. *P<0.05 vs. untreated control and **P<0.05 vs. treatment with LPS alone.