HLA DRB1*-DQB1* genotypes from 943 multiple sclerosis patients and 362 healthy siblings, plus 2829 pseudocontrols obtained from healthy parents of the 943 trio families.

Genetic Dissection of the Human Leukocyte Antigen Region by Use of Haplotypes of Tasmanians with Multiple Sclerosis

Rubio, Justin P.
Bahlo, Melanie
Butzkueven, Helmut
van der Mei, Ingrid A.F.
Sale, Michèle M.
Dickinson, Joanne L.
Groom, Patricia
Johnson, Laura J.
Simmons, Rex D.
Tait, Brian
Varney, Mike
Taylor, Bruce
Dwyer, Terence
Williamson, Robert
Gough, Nicholas M.
Kilpatrick, Trevor J.
Speed, Terence P.
Foote, Simon J.

May 2002

Association of multiple sclerosis (MS) with the human leukocyte antigen (HLA) class II haplotype DRB...

Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance.

Dyment, D
Herrera, B
Cader, M
Willer, C
Lincoln, MR
Sadovnick, A
Risch, N
Ebers, G

January 2005

Mechanisms for observed associations within the major histocompatibility complex (MHC) and autoimmun...

An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus.

DeLuca, GC
Ramagopalan, SV
Herrera, BM
Dyment, DA
Lincoln, MR
Montpetit, A
Pugliatti, M
Barnardo, MC
Risch, NJ
Sadovnick, AD
Chao, M
Sotgiu, S
Hudson, TJ
Ebers, GC

December 2007

Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed f...

Inheritance of HLA-DRB1*16:01-DQB1*05:02 (16) in the absence of the negatively associated HLA-DRB1*15:02-DQB1*06:0, the positively associated DRB1*03:01-DQB1*02:01, DRB1*13:03-DQB1*03:01, DRB1*15:01-DQB1*06:02 and DRB1*04:05-DQB1*03:01. X = “neutral” haplotypes.

Eleonora Cocco (314181)
Claudia Sardu (326610)
Enrico Pieroni (326611)
Maria Valentini (326612)
Raffaele Murru (314191)
Gianna Costa (85210)
Stefania Tranquilli (314187)
Jessica Frau (319808)
Giancarlo Coghe (326613)
Nicola Carboni (314209)
Matteo Floris (31127)
Paolo Contu (326614)
Maria Giovanna Marrosu (314216)

February 2013

X = all other alleles “neutral” haplotypes.Legend: HLA-DRB1*16:01-DQB1*05:02 (16); “neutra...

Sequencing of the HLA-DRB1 promoter region in 156 subjects of Sardinian descent (112 healthy individuals and 44 multiple sclerosis affected individuals) carrying HLA-DRB1-DQA1-DQB1 haplotypes.

Eleonora Cocco (314181)
Alessandra Meloni (314183)
Maria Rita Murru (314185)
Daniela Corongiu (85211)
Stefania Tranquilli (314187)
Elisabetta Fadda (314189)
Raffaele Murru (314191)
Lucia Schirru (314193)
Maria Antonietta Secci (314195)
Gianna Costa (85210)
Isadora Asunis (314197)
Stefania Cuccu (314200)
Giuseppe Fenu (314203)
Lorena Lorefice (314206)
Nicola Carboni (314209)
Gioia Mura (314212)
Maria Cristina Rosatelli (314214)
Maria Giovanna Marrosu (314216)

February 2013

Sequencing of the HLA-DRB1 promoter region in 156 subjects of Sardinian descent (112 healt...

Case-control analysis of HLA-DRB1-DQB1 haplotypes from 2,555 multiple sclerosis patients and 1,365 healthy ethnically matched controls. Only haplotypes represented in at least 1% of the sample were considered.

Eleonora Cocco (314181)
Raffaele Murru (314191)
Gianna Costa (85210)
Amit Kumar (81180)
Enrico Pieroni (326611)
Cristina Melis (400399)
Luigi Barberini (400400)
Claudia Sardu (326610)
Lorena Lorefice (314206)
Giuseppe Fenu (314203)
Jessica Frau (319808)
Giancarlo Coghe (326613)
Nicola Carboni (314209)
Maria Giovanna Marrosu (314216)

April 2013

Pc = P corrected for the 15 considered haplotypes. NS = not significant.Rare haplotypes be...

Frequency of the different DRB1*03:01-containing haplotypes in DRB1*15:01 positive (+) and negative (−) multiple sclerosis (MS) patients and in controls; and case-control study for the total MS patients.

Emilio G. de la Concha (332491)
María L. Cavanillas (166735)
M. Carmen Cénit (332493)
Elena Urcelay (166730)
Rafael Arroyo (105688)
Óscar Fernández (3684697)
José C. Álvarez-Cermeño (332496)
Laura Leyva (166750)
Luisa M. Villar (332498)
Concepción Núñez (183144)

February 2013

% are referred to the total number of haplotypes analysed in each group (last row).AH 18.2...

Inheritance of HLA-DRB1*16:01-DQB1*05:02 in the absence of the negatively associated HLA-DRB1*15:02-DQB1*06:01.

Eleonora Cocco (314181)
Claudia Sardu (326610)
Enrico Pieroni (326611)
Maria Valentini (326612)
Raffaele Murru (314191)
Gianna Costa (85210)
Stefania Tranquilli (314187)
Jessica Frau (319808)
Giancarlo Coghe (326613)
Nicola Carboni (314209)
Matteo Floris (31127)
Paolo Contu (326614)
Maria Giovanna Marrosu (314216)

February 2013

Legend: HLA-DRB1*16:01-DQB1*05:02 (16); X includes the positively associated DRB1*03:01-DQB1*02:0...

The inheritance of HLA-DRB1*15:02-DQB1*06:01 (*15:02) in the absence of HLA-DRB1*16:01-DQB1*05:02.

Eleonora Cocco (314181)
Claudia Sardu (326610)
Enrico Pieroni (326611)
Maria Valentini (326612)
Raffaele Murru (314191)
Gianna Costa (85210)
Stefania Tranquilli (314187)
Jessica Frau (319808)
Giancarlo Coghe (326613)
Nicola Carboni (314209)
Matteo Floris (31127)
Paolo Contu (326614)
Maria Giovanna Marrosu (314216)

February 2013

Legend: HLA-DRB1*15:02-DQB1*06:01 (*15:02); X includes the positively associated DRB1*03:01-DQB1*...

Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet 2006;15:2813–2824. [PubMed: 16905561

Lisa F. Barcellos
Stephen Sawcer
Patricia P. Ramsay
Sergio E. Baranzini
Glenys Thomson
Farren Briggs
Bruce C. A. Cree
Ann B. Begovich
Pablo Villoslada
Xavier Montalban
Antonio Uccelli
Giovanni Savettieri
Robin R. Lincoln
Carolyn Deloa
Jonathan L. Haines
Margaret A. Pericak-vance
Alastair Compston
Stephen L. Hauser
Jorge R. Oksenberg

November 2015

Variation in major histocompatibility complex genes on chromosome 6p21.3, specifically the human leu...

High Resolution Haplotype Analyses of Classical HLA Genes in Families With Multiple Sclerosis Highlights the Role of HLA-DP Alleles in Disease Susceptibility.

Osoegawa, Kazutoyo
Creary, Lisa E
Montero-Martín, Gonzalo
Mallempati, Kalyan C
Gangavarapu, Sridevi
Caillier, Stacy J
Santaniello, Adam
Isobe, Noriko
Hollenbach, Jill A
Hauser, Stephen L
Oksenberg, Jorge R
Fernández-Viňa, Marcelo A

January 2021

Multiple sclerosis (MS) susceptibility shows strong genetic associations with HLA alleles and haplot...

Highly conserved extended haplotypes of the major histocompatibility complex and their relationship to multiple sclerosis susceptibility - Fig 5

Douglas S. Goodin (109752)
Pouya Khankhanian (551089)
Pierre-Antoine Gourraud (91664)
Nicolas Vince (4849513)

February 2018

Disease-associations for the different SNP-haplotype combinations with the Class II HLA haplotype...

Mapping of a susceptibility gene for multiple sclerosis to the 51 kb interval between G511525 and D6S1666 using a new method of haplotype sharing analysis

Nolte, IM
Bruinenberg, M
Spijker, GT
Terpstra, P
Raelson, J
De Keyser, J
Zwanikken, CP
Hulsbeek, M
Hofstra, RMW
Buys, CHCM
Meerman, GJT

October 2001

Multiple sclerosis (MS) is a complex disease that is partly genetic in origin. Although an associati...

Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility.

Lincoln, MR
Ramagopalan, SV
Chao, MJ
Herrera, BM
Deluca, GC
Orton, SM
Dyment, DA
Sadovnick, AD
Ebers, GC

May 2009

Multiple sclerosis (MS), a common central nervous system inflammatory disease, has a major heritable...

Evidence of Linkage with HLA-DR in DRB1*15-Negative Families with Multiple Sclerosis

Ligers, Arturs
Dyment, David A.
Willer, Cristen J.
Sadovnick, A. Dessa
Ebers, George
Risch, Neil
Hillert, Jan

October 2001

The importance of the HLA-DR locus to multiple sclerosis (MS) susceptibility was assessed in 542 sib...

Genetic Dissection of the Human Leukocyte Antigen Region by Use of Haplotypes of Tasmanians with Multiple Sclerosis

Rubio, Justin P.
Bahlo, Melanie
Butzkueven, Helmut
van der Mei, Ingrid A.F.
Sale, Michèle M.
Dickinson, Joanne L.
Groom, Patricia
Johnson, Laura J.
Simmons, Rex D.
Tait, Brian
Varney, Mike
Taylor, Bruce
Dwyer, Terence
Williamson, Robert
Gough, Nicholas M.
Kilpatrick, Trevor J.
Speed, Terence P.
Foote, Simon J.

May 2002

Association of multiple sclerosis (MS) with the human leukocyte antigen (HLA) class II haplotype DRB...

Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance.

Dyment, D
Herrera, B
Cader, M
Willer, C
Lincoln, MR
Sadovnick, A
Risch, N
Ebers, G

January 2005

Mechanisms for observed associations within the major histocompatibility complex (MHC) and autoimmun...

An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus.

DeLuca, GC
Ramagopalan, SV
Herrera, BM
Dyment, DA
Lincoln, MR
Montpetit, A
Pugliatti, M
Barnardo, MC
Risch, NJ
Sadovnick, AD
Chao, M
Sotgiu, S
Hudson, TJ
Ebers, GC

December 2007

Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed f...

Inheritance of HLA-DRB1*16:01-DQB1*05:02 (16) in the absence of the negatively associated HLA-DRB1*15:02-DQB1*06:0, the positively associated DRB1*03:01-DQB1*02:01, DRB1*13:03-DQB1*03:01, DRB1*15:01-DQB1*06:02 and DRB1*04:05-DQB1*03:01. X = “neutral” haplotypes.

Eleonora Cocco (314181)
Claudia Sardu (326610)
Enrico Pieroni (326611)
Maria Valentini (326612)
Raffaele Murru (314191)
Gianna Costa (85210)
Stefania Tranquilli (314187)
Jessica Frau (319808)
Giancarlo Coghe (326613)
Nicola Carboni (314209)
Matteo Floris (31127)
Paolo Contu (326614)
Maria Giovanna Marrosu (314216)

February 2013

X = all other alleles “neutral” haplotypes.Legend: HLA-DRB1*16:01-DQB1*05:02 (16); “neutra...

Sequencing of the HLA-DRB1 promoter region in 156 subjects of Sardinian descent (112 healthy individuals and 44 multiple sclerosis affected individuals) carrying HLA-DRB1-DQA1-DQB1 haplotypes.

Eleonora Cocco (314181)
Alessandra Meloni (314183)
Maria Rita Murru (314185)
Daniela Corongiu (85211)
Stefania Tranquilli (314187)
Elisabetta Fadda (314189)
Raffaele Murru (314191)
Lucia Schirru (314193)
Maria Antonietta Secci (314195)
Gianna Costa (85210)
Isadora Asunis (314197)
Stefania Cuccu (314200)
Giuseppe Fenu (314203)
Lorena Lorefice (314206)
Nicola Carboni (314209)
Gioia Mura (314212)
Maria Cristina Rosatelli (314214)
Maria Giovanna Marrosu (314216)

February 2013

Sequencing of the HLA-DRB1 promoter region in 156 subjects of Sardinian descent (112 healt...

Case-control analysis of HLA-DRB1-DQB1 haplotypes from 2,555 multiple sclerosis patients and 1,365 healthy ethnically matched controls. Only haplotypes represented in at least 1% of the sample were considered.

Eleonora Cocco (314181)
Raffaele Murru (314191)
Gianna Costa (85210)
Amit Kumar (81180)
Enrico Pieroni (326611)
Cristina Melis (400399)
Luigi Barberini (400400)
Claudia Sardu (326610)
Lorena Lorefice (314206)
Giuseppe Fenu (314203)
Jessica Frau (319808)
Giancarlo Coghe (326613)
Nicola Carboni (314209)
Maria Giovanna Marrosu (314216)

April 2013

Pc = P corrected for the 15 considered haplotypes. NS = not significant.Rare haplotypes be...

Frequency of the different DRB1*03:01-containing haplotypes in DRB1*15:01 positive (+) and negative (−) multiple sclerosis (MS) patients and in controls; and case-control study for the total MS patients.

Emilio G. de la Concha (332491)
María L. Cavanillas (166735)
M. Carmen Cénit (332493)
Elena Urcelay (166730)
Rafael Arroyo (105688)
Óscar Fernández (3684697)
José C. Álvarez-Cermeño (332496)
Laura Leyva (166750)
Luisa M. Villar (332498)
Concepción Núñez (183144)

February 2013

% are referred to the total number of haplotypes analysed in each group (last row).AH 18.2...

Inheritance of HLA-DRB1*16:01-DQB1*05:02 in the absence of the negatively associated HLA-DRB1*15:02-DQB1*06:01.

Eleonora Cocco (314181)
Claudia Sardu (326610)
Enrico Pieroni (326611)
Maria Valentini (326612)
Raffaele Murru (314191)
Gianna Costa (85210)
Stefania Tranquilli (314187)
Jessica Frau (319808)
Giancarlo Coghe (326613)
Nicola Carboni (314209)
Matteo Floris (31127)
Paolo Contu (326614)
Maria Giovanna Marrosu (314216)

February 2013

Legend: HLA-DRB1*16:01-DQB1*05:02 (16); X includes the positively associated DRB1*03:01-DQB1*02:0...

The inheritance of HLA-DRB1*15:02-DQB1*06:01 (*15:02) in the absence of HLA-DRB1*16:01-DQB1*05:02.

Eleonora Cocco (314181)
Claudia Sardu (326610)
Enrico Pieroni (326611)
Maria Valentini (326612)
Raffaele Murru (314191)
Gianna Costa (85210)
Stefania Tranquilli (314187)
Jessica Frau (319808)
Giancarlo Coghe (326613)
Nicola Carboni (314209)
Matteo Floris (31127)
Paolo Contu (326614)
Maria Giovanna Marrosu (314216)

February 2013

Legend: HLA-DRB1*15:02-DQB1*06:01 (*15:02); X includes the positively associated DRB1*03:01-DQB1*...

Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet 2006;15:2813–2824. [PubMed: 16905561

Lisa F. Barcellos
Stephen Sawcer
Patricia P. Ramsay
Sergio E. Baranzini
Glenys Thomson
Farren Briggs
Bruce C. A. Cree
Ann B. Begovich
Pablo Villoslada
Xavier Montalban
Antonio Uccelli
Giovanni Savettieri
Robin R. Lincoln
Carolyn Deloa
Jonathan L. Haines
Margaret A. Pericak-vance
Alastair Compston
Stephen L. Hauser
Jorge R. Oksenberg

November 2015

Variation in major histocompatibility complex genes on chromosome 6p21.3, specifically the human leu...

High Resolution Haplotype Analyses of Classical HLA Genes in Families With Multiple Sclerosis Highlights the Role of HLA-DP Alleles in Disease Susceptibility.

Osoegawa, Kazutoyo
Creary, Lisa E
Montero-Martín, Gonzalo
Mallempati, Kalyan C
Gangavarapu, Sridevi
Caillier, Stacy J
Santaniello, Adam
Isobe, Noriko
Hollenbach, Jill A
Hauser, Stephen L
Oksenberg, Jorge R
Fernández-Viňa, Marcelo A

January 2021

Multiple sclerosis (MS) susceptibility shows strong genetic associations with HLA alleles and haplot...

Highly conserved extended haplotypes of the major histocompatibility complex and their relationship to multiple sclerosis susceptibility - Fig 5

Douglas S. Goodin (109752)
Pouya Khankhanian (551089)
Pierre-Antoine Gourraud (91664)
Nicolas Vince (4849513)

February 2018

Disease-associations for the different SNP-haplotype combinations with the Class II HLA haplotype...

Mapping of a susceptibility gene for multiple sclerosis to the 51 kb interval between G511525 and D6S1666 using a new method of haplotype sharing analysis

Nolte, IM
Bruinenberg, M
Spijker, GT
Terpstra, P
Raelson, J
De Keyser, J
Zwanikken, CP
Hulsbeek, M
Hofstra, RMW
Buys, CHCM
Meerman, GJT

October 2001

Multiple sclerosis (MS) is a complex disease that is partly genetic in origin. Although an associati...

Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility.

Lincoln, MR
Ramagopalan, SV
Chao, MJ
Herrera, BM
Deluca, GC
Orton, SM
Dyment, DA
Sadovnick, AD
Ebers, GC

May 2009

Multiple sclerosis (MS), a common central nervous system inflammatory disease, has a major heritable...

Evidence of Linkage with HLA-DR in DRB1*15-Negative Families with Multiple Sclerosis

Ligers, Arturs
Dyment, David A.
Willer, Cristen J.
Sadovnick, A. Dessa
Ebers, George
Risch, Neil
Hillert, Jan

October 2001

The importance of the HLA-DR locus to multiple sclerosis (MS) susceptibility was assessed in 542 sib...

Genetic Dissection of the Human Leukocyte Antigen Region by Use of Haplotypes of Tasmanians with Multiple Sclerosis

Rubio, Justin P.
Bahlo, Melanie
Butzkueven, Helmut
van der Mei, Ingrid A.F.
Sale, Michèle M.
Dickinson, Joanne L.
Groom, Patricia
Johnson, Laura J.
Simmons, Rex D.
Tait, Brian
Varney, Mike
Taylor, Bruce
Dwyer, Terence
Williamson, Robert
Gough, Nicholas M.
Kilpatrick, Trevor J.
Speed, Terence P.
Foote, Simon J.

May 2002

Association of multiple sclerosis (MS) with the human leukocyte antigen (HLA) class II haplotype DRB...

Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance.

Dyment, D
Herrera, B
Cader, M
Willer, C
Lincoln, MR
Sadovnick, A
Risch, N
Ebers, G

January 2005

Mechanisms for observed associations within the major histocompatibility complex (MHC) and autoimmun...

An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus.

DeLuca, GC
Ramagopalan, SV
Herrera, BM
Dyment, DA
Lincoln, MR
Montpetit, A
Pugliatti, M
Barnardo, MC
Risch, NJ
Sadovnick, AD
Chao, M
Sotgiu, S
Hudson, TJ
Ebers, GC

December 2007

Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed f...

HLA DRB1-DQB1 genotypes from 943 multiple sclerosis patients and 362 healthy siblings, plus 2829 pseudocontrols obtained from healthy parents of the 943 trio families.

Abstract

Extracted data

HLA DRB1-DQB1 genotypes from 943 multiple sclerosis patients and 362 healthy siblings, plus 2829 pseudocontrols obtained from healthy parents of the 943 trio families.

Abstract

Extracted data

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