Suppression of HIV replication by HIV-TCR containing T cells.

<p><b>A.</b> Suppression of HIV-1 induced CD4 cell depletion by cells containing HIV-specific TCR. Mice containing cells derived from HSC transduced with either HIV Gag SL9-epitope specific TCR (n = 6 mice) or a non-specific control TCR (n = 7 mice) were infected with HIV-1_HSA-HA or left uninfected (n = 4 mice)(SL9-specific TCR containing mice) and assessed 2 weeks and 6 weeks following infection for peripheral human CD45+, CD4+ cells. Statistical comparison of CD4 cell depletion to uninfected controls was performed using the Student's t test, p values are provided for each indicated comparison. The solid lines represent the mean +/− the standard error of the mean (SEM). <b>B.</b> Suppression of HIV expressing cells. Mice treated as described in (A) were assessed for human CD45+ cells expressing HIV by flow cytometry for the HSA-HA marker gene. Comparison of HIV expression levels between SL-9 containing and control TCR-containing mice are provided at week 2 and week 6 post infection (Student's t test). The data represent 1 experiment of 3, with a minimum of 3 mice per experimental condition, and is a separate experiment than that depicted in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1002649#ppat-1002649-g002" target="_blank">Figure 2</a>.