Profile of infiltrating cells in the colon and mesenteric lymph nodes during DSS-induced colitis in mice treated with bortezomib or control.

<p>(<b>A</b>) The numbers of neutrophils, CD4⁺ T cells, CD8⁺ T cells, B220⁺ B cells, and F4/80⁺ macrophages per one field of view (×200) in the colon were counted. (<b>B</b>) Bortezomib affects CD4⁺ and CD8⁺ T cell numbers in mesenteric lymph nodes during DSS-induced colitis. Bar graphs indicate CD4⁺ T cells, CD8⁺ T cells, and B220⁺ cells in mesenteric lymph nodes 7 days after induction of colitis. A, B) Values represent means (± SEM) from ≥4 mice per group. Significant differences between sample means are indicated: *<i>P</i><0.05. Similar results were obtained in at least two independent experiments.