SapC-DOPS-CVM localizes to arthritic joints in CIA.

<p>(A) Light images of DBA/1 mice treated with CII (left, CIA) and non-CII treated (right, Control). (B) IVIS® images of mice in A, 48 hours following SapC-DOPS-CVM i.v injection. Light images of CIA hind paw (C) and forepaw (E) with corresponding IVIS® images in (D) and (F). Solid black arrows indicate macroscopically swollen paws and white arrows indicate macroscopically swollen joints. (G) and (I) IVIS® images of CII-treated mice 48 hours following SapC-DOPS-CVM i.v. injection, with arrows indicating corresponding histological knee sections (H) and (J) stained with hematoxylin and eosin. CVM intensity as measured by live fluorometric imaging is represented by red, yellow, green, blue colorimetric scale with red representing highest and blue representing lowest intensity.