Rapamycin reduces proliferation in obstructed kidneys.

<p>Animals were treated as decribed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033626#s2" target="_blank">Methods</a>. A(A′)–F(F′): Representative sections from kidneys with [D(D′)–F(F′)] or without [A(A′)–C(C′)] rapamycin treatment, using anti-ki67 for immunohistochemistry. Ki67 postive cells are labeled with brown staining. High-power micrographs are presented as inserted images (A′–F′). Scale bar: 50 µm. G–H: Quantitative analysis of Ki67+ tubular cells (G) and interstitial cells(H) in representative kidney sections. n = 5 animals for each group. **P<0.01 vs. vehicle-treated groups. NS no significance. Error bars represent S.E.