PLC restores the impaired responses to glucose overload and insulin administration induced by high-fat (HF) fed animals.

<p>A, B and C: Intraperitoneal glucose tolerance test performed in overnight fasted animals. A: Plasma glucose concentrations at baseline and at 30, 60, 90 and 120 minutes after glucose overload (2 mg/kg). B: Incremental glucose concentrations at 30, 60, 90 and 120 minutes after glucose overload. C: Area under curves describing the increase of glycaemia from 0 to 120 minutes after the glucose overload. D, E and F: Insulin sensitivity test. D. Plasma glucose concentrations at baseline and at 30, 60, 90 and 120 after insulin administration (0.8 U/kg body weight). E: Decrease of glycaemia suffered at 30, 60, 90 and 120 after insulin injection. F Area under curves describing the decrease of glycaemia from 0 to 120 minutes after the insulin administration. Values are means and SEM (n = 10). ^##<i>P</i><0.01, ^###<i>P</i><0.001 <i>vs</i> vehicle-ST, *<i>P</i><0.05 <i>vs</i> vehicle-HF.