<p>(A) Hematological parameters, spleen size, and iron content in primary, secondary and tertiary chimeras. (B) HPLC profiles of <i>Hbb<sup>th3+</sup></i> control mouse (upper left quadrant) compared to primary (right upper quadrant), secondary (left lower quadrant) and tertiary (right lower quadrant) BMT chimeras transplanted with AnkT9W-treated BM cells. (C) Cellulose acetate of primary (top) and secondary (bottom) BMT chimeras.</p
Hematopoietic stem cells (HSCs) are regulated by signals from the bone marrow (BM) niche, which tune...
<p>Survival after allogeneic BMT in a C57BL/6 (B6)→BALB/c mouse model (n = 15) of acute GVHD (<b>—</...
(A) Chimerism study of the peripheral blood from CD45.1+ recipient mice transplanted with BMMCs (2x1...
<p>(A) Flow cytometry. CD71/Ter119 antibodies (y/x axes, respectively) were utilized to assess the c...
PubMed ID: 16339691Stable mixed chimeric stem cell transplantation in hemoglobinopathies exploits sh...
AbstractGene therapy, the replacement of normal human beta- or gamma-globin genes into the hematopoi...
Mouse models for the cure of β-thalassemia and sickle cell anemia L. BREDA, S. RIVELLA Beta-thalasse...
<p>Representative cardiac macroscopic phenotype of 15-months control (A) and homo-βthal (B) show imp...
<p>Results of the flow cytometric analysis of the bone marrow (A) and spleen (B). The black bar indi...
Deletion of the murine beta-major globin gene on chromosome 7 causes a severe, hypochromic anemia in...
Beta-thalassemia results from mutations of the β-hemoglobin (Hbb) gene and reduced functional Hbb sy...
<p>Representative FACS plots from wild-type (B6, MRL) and chimeric mice (B6 Chimera, MRL Chimera).Ch...
WOS: 000187122000059PubMed ID: 12933586Bone marrow transplantation (BMT) is the only curative therap...
Beta-thalassemia results from mutations of the β-hemoglobin (Hbb) gene and reduced functional Hbb sy...
We have used a "plug and socket" targeting technique to generate a mouse model of beta 0-thalassemia...
Hematopoietic stem cells (HSCs) are regulated by signals from the bone marrow (BM) niche, which tune...
<p>Survival after allogeneic BMT in a C57BL/6 (B6)→BALB/c mouse model (n = 15) of acute GVHD (<b>—</...
(A) Chimerism study of the peripheral blood from CD45.1+ recipient mice transplanted with BMMCs (2x1...
<p>(A) Flow cytometry. CD71/Ter119 antibodies (y/x axes, respectively) were utilized to assess the c...
PubMed ID: 16339691Stable mixed chimeric stem cell transplantation in hemoglobinopathies exploits sh...
AbstractGene therapy, the replacement of normal human beta- or gamma-globin genes into the hematopoi...
Mouse models for the cure of β-thalassemia and sickle cell anemia L. BREDA, S. RIVELLA Beta-thalasse...
<p>Representative cardiac macroscopic phenotype of 15-months control (A) and homo-βthal (B) show imp...
<p>Results of the flow cytometric analysis of the bone marrow (A) and spleen (B). The black bar indi...
Deletion of the murine beta-major globin gene on chromosome 7 causes a severe, hypochromic anemia in...
Beta-thalassemia results from mutations of the β-hemoglobin (Hbb) gene and reduced functional Hbb sy...
<p>Representative FACS plots from wild-type (B6, MRL) and chimeric mice (B6 Chimera, MRL Chimera).Ch...
WOS: 000187122000059PubMed ID: 12933586Bone marrow transplantation (BMT) is the only curative therap...
Beta-thalassemia results from mutations of the β-hemoglobin (Hbb) gene and reduced functional Hbb sy...
We have used a "plug and socket" targeting technique to generate a mouse model of beta 0-thalassemia...
Hematopoietic stem cells (HSCs) are regulated by signals from the bone marrow (BM) niche, which tune...
<p>Survival after allogeneic BMT in a C57BL/6 (B6)→BALB/c mouse model (n = 15) of acute GVHD (<b>—</...
(A) Chimerism study of the peripheral blood from CD45.1+ recipient mice transplanted with BMMCs (2x1...