Model depicting heat shock adaptation in <i>C. albicans</i>.

<p>In this minimal molecular model of heat shock response the arrows represent mass flow or chemical reaction. The numbers in circles specify the respective step in the model. The lines ended with circles indicate positive regulation and lines with blind ends indicate negative regulation. Dashed arrows represent transcription (9) or translation (11) of <i>HSP90</i>. See text for detailed description of the molecular mechanism: Hsp90_complex, Hsp90 complexes with unfolded proteins; K and K*, inactive and active forms of an activating protein kinase; I and I*, inactive and active forms of an inactivating protein phosphatase.