The figure indicates parameters of HRV in patients, relatives and controls.

<p>Increased mean heart rates of patients and relatives are depicted in A. Decreased parasympathetic modulation is shown in B by means of the RMSSD and in C using the high frequency band of heart rate. Reduced complexity is shown for patients and relatives in D. Respiratory sinus arrhythmia (E) indicates low cardiac vagal modulation in patients and relatives. Transfer function (F) shows that decreased cardiac vagal modulation in patients and relatives is independent from the respiratory rate. Boxes indicate data between the 25th and 75th percentile with the horizontal bar reflecting the median (□ = mean; - = 1st and 99th percentile; x = minimum and maximum of data). Significant differences of Bonferoni corrected pair-wise comparisons are indicated: * p<.05; ** p<.01; *** p<.001.