Upregulation of BDNF and TrkB in RVLM during experimental TLSE.

<p>Fold-changes in BDNF or TrkB mRNA against sham-control detected by real-time PCR (A,C), temporal changes in tissue levels of BDNF detected by ELISA (B) or TrkB detected by Western blot analysis (D) in tissues collected from bilateral RVLM 180 min (A,C,D) or 1, 2 or 3 h (B) after microinjection of KA (0.5 nmol) or PBS into the left hippocampal CA3 subfield. Values are mean ± SEM of triplicate analyses from 5–6 animals per experimental group. *<i>P</i><0.05 versus sham-control or PBS group in the post hoc Scheffé multiple-range test.