CAR post-treatment reduced infarct volume after cerebral I/R injury.

<p>CAR was administered (i.p. and i.c.v.) at different reperfusion times after 75 min of ischemia. TTC staining for cerebral infarct volume was performed after 24 h reperfusion. (A) Mice were administered CAR (50 mg/kg, i.p.) and saline at 0 h, 2 h, and 4 h after reperfusion. CAR had no protection on infarct volume when it was administered at 4 h after reperfusion. (B) Mice were administered with 10 µg CAR (i.c.v.) or saline at 2 h, 4 h, 6 h, and 7 h after reperfusion. CAR still had protective effect when mice treated with CAR after 6 h of reperfusion. Bars represent mean ± SEM of 6 brains. *, <i>P</i><0.05 versus vehicle-treated I/R group.