Effect of MSCs on the clinical and colonoscopic parameters of the colitis model.

<p>Survival did not differ significantly among experimental groups. Of the TNBS-colitic animals, 2 treated with vehicle died on days 4 and 7, and 1 treated with BM-MSCs died on day 9. Survival was analyzed by the Kaplan–Meier log-rank test (A). Following TNBS-induction, animals presented a progressive weight loss compared with controls (*p<0.001). After receiving AT- or BM-MSCs, animals gradually regained weight, in contrast to vehicle-treated animals (**p<0.046; ***p<0.004) (B). Colonoscopic imaging was obtained after colitis induction at day 4, and after MSCs administration at day 11. In control experiments, colonoscopy was performed following intra-rectal saline enemas, and intraperitoneal administration of vehicle in TNBS-induced animals (C). Differences before and after treatment were evaluated with the Wilcoxon matched-pair signed rank test. Values are mean±S.E.M. of 10 animals/group.