Riccardin D inhibited angiogenesis in intestinal polyps.

<p>(A): Immunohistochemical staining of CD34 for analysis of microvessel density (MVD) in polyps of 2–3 mm on small intestines and colons. MVD in polyps of different intestine segments was significantly inhibited by Riccardin D. (B): The expression of VEGF in polyps was inhibited by Riccardin D as estimated by immunohistochemical staining assay. The bars represent mean ± S.D. of six animals. *, p<0.001 <i>versus</i> control. (C): Riccardin D decreased the expression of FGF-2 in intestinal polyps as estimated by western blotting assay (n = 3).