Density of immuno-gold labeled glutamate in asymmetric terminals.

<p>(A) In VGLUT1- labeled terminals there was no change in glutamate density with 6OHDA lesions. In 6OHDA-lesioned rats, STN lesions resulted in a decrease in glutamate particle density in VGLUT1-immunolabeled terminals (p<0.05), as did STN stimulation (p<0.01). 6OHDA-lesioned rats which underwent STN electrode placement alone did not show significant changes compared with 6OHDA alone. (B) Glutamate immuno-gold particle density in non-VGLUT1-immunolabeled terminals. There was no change in glutamate density in 6OHDA-lesioned rats in non-VGLUT1-immunolabeled, thalamostriatal terminals. There was a decrease in glutamate particle density with STN stimulation (p<0.02) as compared with controls, although only a trend to decrease (p<0.09) compared with 6OHDA-lesioned rats. The decrease with 6OHDA+STN lesions was not significant.